AdipoGen Life Sciences

Progranulin (rat) (rec.) (untagged)

Product Code:
 
AG-40A-0196Y
Product Group:
 
Recombinant Proteins
Antibody Isotype:
 
n/a
Antibody Clone:
 
n/a
Regulatory Status:
 
RUO
Target Species:
 
Bovine (Cattle)
Shipping:
 
Blue Ice
Storage:
 
Short term: +4°C. Long term: -20°C
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Deglycosylation of rat progranulin. To examine the deglycosylation of rat progranulin, 1?g of rat progranulin is denatured with 1X glycoprotein denaturing buffer at 100?C for 10 minutes. After the addition of NP-40 and G7 reaction buffer, twofol
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Deglycosylation of rat progranulin. To examine the deglycosylation of rat progranulin, 1?g of rat progranulin is denatured with 1X glycoprotein denaturing buffer at 100?C for 10 minutes. After the addition of NP-40 and G7 reaction buffer, twofol

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AG-40A-0196Y-C01010 ug£181.00
Quantity:
AG-40A-0196Y-C05050 ug£421.00
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This product comes from: Switzerland.
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Further Information

Alternate Names/Synonyms:
Proepithelin; PEPI; PC Cell-derived Growth Factor
Concentration:
After reconstitution:for 10µg size: 0.1mg/mlfor 50µg size: 1 mg/ml
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Centrifuge lyophilized vial before opening and reconstitution.Do not freeze/thaw.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. Signal peptide and rat progranulin (aa 1-602) is untagged. Reflects the native sequence with no additional aa. Source: HEK 293 cells. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Purity: >95% (SDS-PAGE). Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
Molecular Weight:
~73kDa (SDS-PAGE)
NCBI, Uniprot Number:
NCBI Gene link NP_058809
Package Type:
Plastic Vial
Product Description:
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
Purity:
>95% (SDS-PAGE)
Sequence:
Signal peptide and rat progranulin (aa 1-602) is untagged. Reflects the native sequence with no additional aa.
Source / Host:
HEK 293 cells
TAGs:
no TAG
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.