Theacrine
Product Code: AG-CN2-0466
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0466-M100 | 100 mg | £60.00 |
Quantity:
| AG-CN2-0466-G001 | 1 g | £125.00 |
Quantity:
| AG-CN2-0466-G005 | 5 g | £280.00 |
Quantity:
| AG-CN2-0466-G025 | 25 g | £580.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Isotype: n/a
Antibody Clone: n/a
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+20°C
Documents
Further Information
Alternate Names/Synonyms:
NSC8809; Temorine; 1,3,7,9-Tetramethyluric acid; TetraMUA
Appearance:
White to off-white solid.
CAS:
2309-49-1
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Protect from light.
InChi:
InChI=1S/C9H12N4O3/c1-10-5-6(11(2)8(10)15)12(3)9(16)13(4)7(5)14/h1-4H3
InChiKey:
QGDOQULISIQFHQ-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 2309-49-1. Formula: C9H12N4O3. MW: 224.2. Synthetic. Originally isolated from Theobroma grandiflorum. Purine alkaloid related to caffeine. Potent antioxidant. Not through direct scavenging of ROS but strengthen antioxidant systems in vivo. Anti-inflammatory and antinociceptive compound. Suggested to have adenosine receptor agonistic activity and also acting on dopamine receptors. Shown to have potent sedative and hypnotic properties. Ameliorated learning and memory impairments caused by central fatigue. Shown to inhibit cAMP-specific PDE4 and cGMP-specific PDE5 activity in vivo and in vitro. Increased glucose level, decreased lactic acid concentration, reduced LDH activity and elevated the expressions of both GLUT1/3 in restraint-stressed mice. Can increase the solubility of aromatic systems in water.
MDL:
MFCD00042781
Molecular Formula:
C9H12N4O3
Molecular Weight:
224.2
Package Type:
Vial
Product Description:
Purine alkaloid related to caffeine. Potent antioxidant. Not through direct scavenging of ROS but strengthen antioxidant systems in vivo. Anti-inflammatory and antinociceptive compound. Suggested to have adenosine receptor agonistic activity and also acting on dopamine receptors. Shown to have potent sedative and hypnotic properties. Ameliorated learning and memory impairments caused by central fatigue. Shown to inhibit cAMP-specific PDE4 and cGMP-specific PDE5 activity in vivo and in vitro. Increased glucose level, decreased lactic acid concentration, reduced LDH activity and elevated the expressions of both GLUT1/3 in restraint-stressed mice. Can increase the solubility of aromatic systems in water.
Purity:
>98% (HPLC)
SMILES:
CN1C(=O)N(C)C2=C1N(C)C(=O)N(C)C2=O
Solubility Chemicals:
Soluble in water (20mg/ml).
Source / Host:
Synthetic. Originally isolated from Theobroma grandiflorum.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
The solubilization of polycyclic aromatic hydrocarbons by purines: H. Weil-Malherbe; Biochem. J. 40, 351 (1946) | 1,3,7,9-Tetramethyluric acid ? a chromosome-damaging agent occurring as a natural metabolite in certain caffeine-producing plants; B.A. Kihlman; Mutat. Res. 39, 297 (1977) | Efficient scavenging of hydroxyl radicals and inhibition of lipid peroxidation by novel analogues of 1,3,7-trimethyluric acid: V.B. Bhat, et al.; Life Sci. 70, 381 (2001) | Caffeine and other xanthines as cytochemical blockers and removers of heterocyclic DNA intercalators from chromatin: M.B. Lyles & I.L. Cameron; Cell Biol. Int. 26, 145 (2002) | Theacrine, a special purine alkaloid with sedative and hypnotic properties from Cammelia assamica var. kucha in mice: J.K. Xu, et al.; J. Asian Nat. Prod. Res. 9, 665 (2007) | Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities: Y. Wang, et al.; Fitoterapia 81, 627 (2010) | Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors: A.A. Feduccia, et al.; Pharmacol. Biochem. Behav. 102, 241 (2012) | Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice: W.X. Li, et al.; J. Agric. Food Chem. 61, 6328 (2013) | Comparing antioxidant capacity of purine alkaloids: A new, efficient trio for screening and discovering potential antioxidants in vitro and in vivo: B. Tsoi, et al.; Food Chem. 176, 411 (2015)