5-Hydroxymethylcytosine
| Code | Size | Price |
|---|
| BVT-0229-M010 | 10 mg | £130.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
5hmC; Demethylbacimethrin
Appearance:
Off-white powder.
CAS:
1123-95-1
EClass:
32160000
Form (Short):
solid
Handling Advice:
Protect from light when in solution.
InChi:
InChI=1S/C5H7N3O2/c6-4-3(2-9)1-7-5(10)8-4/h1,9H,2H2,(H3,6,7,8,10)
InChiKey:
RYVNIFSIEDRLSJ-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1123-95-1. Formula: C5H7N3O2. MW: 141.1. Synthetic. Modified base of mammalian DNA. Involved in regulation of stem cell processes, cellular development, neurodegeneration and carcinogenesis. Important epigenetic marker. Related to bacimethrin (Prod. No. BVT-0226 http://www.adipogen.com/bvt-0226/bacimethrin.html ).
MDL:
MFCD00047369
Molecular Formula:
C5H7N3O2
Molecular Weight:
141.1
Package Type:
Plastic Vial
Product Description:
Modified base of mammalian DNA. Involved in regulation of stem cell processes, cellular development, neurodegeneration and carcinogenesis. Important epigenetic marker. Related to bacimethrin (Prod. No. BVT-0226 http://www.adipogen.com/bvt-0226/bacimethrin.html ).
Purity:
>98% (NMR)
SMILES:
NC1=C(CO)C=NC(=O)N1
Solubility Chemicals:
Soluble in water, DMSO or methanol.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at +4°C. After reconstitution protect from light at -20°C.
References
5-Hydroxymethylcytosine, the sixth base of the genome: M. M?nzel, et al.; Angew. Chem. Int. Ed. 50, 6420 (2011) (Review) | 5-Hydroxymethylcytosine-mediated DNA demethylation in stem cells and development: W. Sun; Stem Cells 23, 923 (2014) (Review) | 5-Hydroxymethylcytosine: an epigenetic mark frequently deregulated in cancer: L. Kroetze, et al.; Biochim. Biophys. Acta 144, 1855 (2015) (Review) | 5-Hydroxymethylcytosine: a new player in brain disorders?: Y. Cheng, et al.; Exp. Neurol. 268, 3 (2015) (Review) | 5-Hydroxymethylcytosine: in cancer: significance in diagnosis and therapy: A. Vasanthakumar & L. A. Godley; Cancer Genet. 208, 167 (2015) (Review) | New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine: E. Moen, et al.; Immunol. Rev. 236, 36 (2015) (Review) | Role of 5-hydroxymethylcytosine in neurodegeneration: S. I. Sherwani & H. A. Khan; Gene 570, 17 (2015) (Review)