MBIMPH F-Analog 2
| Code | Size | Price |
|---|
| AG-CR1-3909-M001 | 1 mg | £150.00 |
Quantity:
| AG-CR1-3909-M005 | 5 mg | £570.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
+4°C (short term), -20°C (long term).
Documents
Further Information
Alternate Names/Synonyms:
MBIMPH Fluorinated Analog 2; 4-((6-Fluoro-2-methyl-1H-benzo[d]imidazol-1-yl)methyl)-N-hydroxybenzamide
Appearance:
Light brown solid.
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Protect from light.
InChi:
InChI=1S/C16H14FN3O2/c1-10-18-14-7-6-13(17)8-15(14)20(10)9-11-2-4-12(5-3-11)16(21)19-22/h2-8,22H,9H2,1H3,(H,19,21)
InChiKey:
QFZFFNKSKDGHQP-UHFFFAOYSA-N
Long Description:
Chemical. Formula: C16H14FN3O2. MW: 299.3. Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =5nM). Displays high selectivity over all other HDACs (IC50=0.2-11µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
Molecular Formula:
C16H14FN3O2
Molecular Weight:
299.3
Package Type:
Vial
Product Description:
Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =5nM). Displays high selectivity over all other HDACs (IC50=0.2-11µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
Purity:
>95% (HPLC)
SMILES:
CC1=NC2=C(C=C(F)C=C2)N1CC1=CC=C(C=C1)C(=O)NO
Solubility Chemicals:
Soluble in DMSO, ethanol or methanol.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Bicyclic-capped histone deacetylase 6 inhibitors with improved activity in a model of axonal charcot-marie-tooth disease: S. Shen, et al.; ACS Chemical Neuroscience (submitted) (2015)
Related Products
| Product Name | Product Code | Supplier | Nexturastat A | AG-CR1-3901 | AdipoGen Life Sciences | Summary Details | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nexturastat B | AG-CR1-3902 | AdipoGen Life Sciences | Summary Details | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ACY-775 | AG-CR1-3903 | AdipoGen Life Sciences | Summary Details | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DMAPB | AG-CR1-3904 | AdipoGen Life Sciences | Summary Details | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PMPH | AG-CR1-3905 | AdipoGen Life Sciences | Summary Details | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DABPH | AG-CR1-3906 | AdipoGen Life Sciences | Summary Details | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| MBIMPH | AG-CR1-3907 | AdipoGen Life Sciences | Summary Details | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| MBIMPH F-Analog 1 . HCl | AG-CR1-3908 | AdipoGen Life Sciences | Summary Details | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||