Zinc-alpha-2-glycoprotein Recombinant Protein
| Code | Size | Price |
|---|
| PSI-90-327-50ug | 50ug | £867.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
Stable for at least 6 months after receipt when stored at -20˚C.
Documents
Further Information
Additional Names:
Zn-alpha-2-GP, Zn-alpha-2-Glycoprotein, ZAG, ZA2G, AZGP1, ZNGP1
Application Note:
This recombinant proteins is for research use only.
Background:
Zinc-alpha-2-glycoprotein (ZAG), first identified in the 1960s, derives its name from its precipitation from human plasma upon the addition of zinc salts. ZAG has since been found in secretory epithelial cells and in a range of body fluids. ZAG is identical to a lipid mobilizing factor isolated from the urine of patients with cancer cachexia and stimulates lipolysis in in vitro and in vivo experiments. Due to its expression in, and secretion from adipocytes, ZAG is considered an adipokine. Recently the clinical significance of ZAG has been clarified. ZAG expression in adipocytes is inversely related to fat mass, thus it is intimately involved in the maintenance of body weight in mice and humans. Epidemiological studies have uncovered an association between ZAG and plasma cholesterol. The non-synonymous single nucleotide polymorphism rs4215 in ZAG is associated with plasma cholesterol and obesity. Structurally ZAG possesses a class I major histocompatibility complex (MHC) protein fold. It is distinct from other members of this protein family in that it is soluble, rather than being anchored to plasma membranes, and it associates with prolactin inducible protein rather than beta2-microglobulin. Similar to peptide antigen-presenting class I MHC molecules, ZAG possesses an open apical groove between its alpha1 and alpha2 domain helices.
Buffer:
Contains PBS. Reconstitute with 50 μl sterile water.
Concentration:
10ug size: 0.1mg/ml after reconstitution.50ug size: 1mg/ml after reconstitution.
Fusion Tag:
Tag Free
NCBI Gene ID #:
563
NCBI Official Name:
alpha-2-glycoprotein 1, zinc-binding
NCBI Official Symbol:
AZGP1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
P25311
Protein GI Number:
292495049
Purity:
>95% (SDS-PAGE).
Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P45481