UBE2G2 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-91-976-0.05mg | 0.05mg | £389.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
Store at -20˚C, stable for 6 months after receipt.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Documents
Further Information
Additional Names:
Ubiquitin-Conjugating Enzyme E2 G2, Ubiquitin Carrier Protein G2, Ubiquitin-Protein Ligase G2, UBE2G2, UBC7
Application Note:
This recombinant protein can be used for biological assays. For research use only.
Background:
Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 100% sequence identity with S. cerevisiae Ubc7 and mouse respectively. The UBE2G2 enzyme and the GP78 E3 ligase are active components of endoplasmic reticulum-associated degradation pathway which is essential for the degradation of misfolded ER proteins. The mechanism of K48-linked poly-ubiquitination by UBE2G2/GP78 appears to involve the transfer of preassembled Ub chains from UBE2G2 to lysine residues in a substrate. The E2 and E3 enzymes form a large hetero-oligomer which brings multiple UBE2G2 molecules into close proximity which allows for Ub transfer between neighboring E2s.
Buffer:
Supplied as a 0.2 um filtered solution of 50mM HEPES, 150mM NaCl, 2mM DTT, 10% Glycerol, pH 7.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Fusion Tag:
N-GST tag
NCBI Gene ID #:
7327
NCBI Official Name:
ubiquitin conjugating enzyme E2 G2
NCBI Official Symbol:
UBE2G2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Predicted Molecular Weight:
45 kD
Protein Accession #:
P60604
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P60604