Incensol
Product Code: AG-CN2-0482
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0482-M001 | 1 mg | £135.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Storage:
Short Term: 4°C Long Term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
(-)-Incensol; (-)-Incensole; (1R,2S,5E,9E,12S)-1,5,9-Trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-ol
Appearance:
Oil.
CAS:
22419-74-5
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.
InChi:
InChI=1S/C20H34O2/c1-15(2)20-12-11-17(4)8-6-7-16(3)9-10-18(21)19(5,22-20)13-14-20/h7,11,15,18,21H,6,8-10,12-14H2,1-5H3/b16-7+,17-11+/t18-,19+,20+/m0/s1
InChiKey:
SSBZLMMXFQMHDP-REDNKFHQSA-N
Long Description:
Chemical. CAS: 22419-74-5. Formula: C20H34O2. MW: 306.5. Isolated from Boswellia papyrifera. Component of the frankincense essential oil. Activator of transient receptor potential vanilloid 3 (TRPV3), a heat-sensitive ion channel involved in skin heat sensitivity, thermoregulation and neurological activities. More powerful TRPV3 agonist than incensol acetate (Prod. No. AG-CN2-0484). Potent inhibitor of STAT3. Showed inhibitory activity on IL-6-induced STAT3 activation. Shown to have COX-1 and COX-2 inhibitory activity and cytotoxic activity against selected cancer cell lines.
MDL:
MFCD31560821
Molecular Formula:
C20H34O2
Molecular Weight:
306.5
Package Type:
Vial
Product Description:
Component of the frankincense essential oil. Activator of transient receptor potential vanilloid 3 (TRPV3), a heat-sensitive ion channel involved in skin heat sensitivity, thermoregulation and neurological activities. More powerful TRPV3 agonist than incensol acetate (Prod. No. AG-CN2-0484). Potent inhibitor of STAT3. Showed inhibitory activity on IL-6-induced STAT3 activation. Shown to have COX-1 and COX-2 inhibitory activity and cytotoxic activity against selected cancer cell lines.
Purity:
>92% (HPLC)
SMILES:
C/C1=CCC/C(C)=C/C[C@]2(C(C)C)CC[C@@](C)(O2)[C@@H](O)CC1
Solubility Chemicals:
Soluble in DMSO, dichloromethane or ethyl ether. Insoluble in water. Almost insoluble in ethanol or methanol.
Source / Host:
Isolated from Boswellia papyrifera.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352211
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri: N. Banno, et al.; J. Ethnopharmacol. 107, 249 (2006) | Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri: T. Akihisa, et al.; Biol. Pharm. Bull. 29, 1976 (2006) | Major constituents of Boswellia carteri resin exhibit cyclooxygenase enzyme inhibition and antiproliferative activity: S.I. Ali, et al.; Nat. Prod. Commun. 8, 1365 (2013) | Neuroactive and anti-inflammatory frankincense cembranes: A structure-activity study: F. Pollastro, et al.; J. Nat. Prod. 79, 1762 (2016)