PF-562271
| Code | Size | Price |
|---|
| SYN-1064-M100 | 100 mg | Enquire |
Quantity:
| SYN-1064-M001 | 1 mg | £104.00 |
Quantity:
| SYN-1064-M005 | 5 mg | £186.00 |
Quantity:
| SYN-1064-M010 | 10 mg | £268.00 |
Quantity:
| SYN-1064-M050 | 50 mg | £771.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
PF562271
Appearance:
Solid.
CAS:
717907-75-0
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Hazards:
H303, H317, H333
InChi:
InChI=1S/C21H20F3N7O3S/c1-31(35(2,33)34)19-12(4-3-7-25-19)10-26-18-15(21(22,23)24)11-27-20(30-18)28-14-5-6-16-13(8-14)9-17(32)29-16/h3-8,11H,9-10H2,1-2H3,(H,29,32)(H2,26,27,28,30)
InChiKey:
MZDKLVOWGIOKTN-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 717907-75-0. Formula: C21H20F3N7O3S. MW: 507.5. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nM, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nM. PF-562,271 was evaluated against multiple kinases and displays >100x selectivity against a long list of nontarget kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/mL using injections.
Molecular Formula:
C21H20F3N7O3S
Molecular Weight:
507.5
Package Type:
Plastic Vial
Precautions:
P261, P272, P280, P302, P352, P333, P313, P321, P363, P501
Product Description:
PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nM, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nM. PF-562,271 was evaluated against multiple kinases and displays >100x selectivity against a long list of nontarget kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/mL using injections.
Purity:
>95%
Signal word:
Warning
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271: W.G. Roberts, et al.; Cancer Res. 68, 1935 (2008) | Selectivity data: assessment, predictions, concordance, and implications. C. Gao, et al.; J. Med. Chem. 56, 6991 (2013) | Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation: J.M. Yang, et al.; Nat. Comm. 9, 4673 (2018)
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