MLN0128
| Code | Size | Price |
|---|
| SYN-1157-M100 | 100 mg | Enquire |
Quantity:
| SYN-1157-M001 | 1 mg | £121.00 |
Quantity:
| SYN-1157-M005 | 5 mg | £197.00 |
Quantity:
| SYN-1157-M010 | 10 mg | £315.00 |
Quantity:
| SYN-1157-M050 | 50 mg | £1,099.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
MLN-0128; INK-128
Appearance:
Solid.
CAS:
1224844-38-5
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19)
InChiKey:
GYLDXIAOMVERTK-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1224844-38-5. Formula: C15H15N7O. MW: 309.3. MLN0128 is a potent and selective mTOR inhibitor with an IC(50) of 1nM; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin).
Molecular Formula:
C15H15N7O
Molecular Weight:
309.3
Package Type:
Plastic Vial
Product Description:
MLN0128 is a potent and selective mTOR inhibitor with an IC(50) of 1nM; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin).
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Dual mTORC1/2 and HER2 blockade results in antitumor activity in preclinical models of breast cancer resistant to anti-HER2 therapy: C. Garc?a-Garc?a, et al.; Clin. Cancer Res. 18, 2603 (2012) | The translational landscape of mTOR signalling steers cancer initiation and metastasis: A.C. Hsieh, et al.; Nature 485, 55 (2012)
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