TASP0415914
| Code | Size | Price |
|---|
| SYN-1208-M100 | 100 mg | Enquire |
Quantity:
| SYN-1208-M050 | 50 mg | Enquire |
Quantity:
| SYN-1208-M001 | 1 mg | £186.00 |
Quantity:
| SYN-1208-M005 | 5 mg | £350.00 |
Quantity:
| SYN-1208-M010 | 10 mg | £502.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
4°C
Documents
Further Information
Alternate Names/Synonyms:
TASP-0415914
Appearance:
Solid.
CAS:
1292300-75-4
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C13H17N5O3S/c1-7-10(22-13(14-7)15-8(2)19)11-16-12(17-21-11)18-5-3-4-9(20)6-18/h9,20H,3-6H2,1-2H3,(H,14,15,19)
InChiKey:
WFQFHKQIDOCQTL-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1292300-75-4. Formula: C13H17N5O3S. MW: 323.4. PI3Kgamma is required for for T-cell and B-cell as well as mast cell migration and degranulation. As such, these kinases are attractive targets for potential anti-infmamatory drugs. TASP0415914 has shown excellent results in cell based assays. It is orally available and has performed will in murine in vivo models. PI3Kgamma IC(50) 29nM, AKT IC(50) 294nM.
Molecular Formula:
C13H17N5O3S
Molecular Weight:
323.4
Package Type:
Plastic Vial
Product Description:
PI3Kgamma is required for for T-cell and B-cell as well as mast cell migration and degranulation. As such, these kinases are attractive targets for potential anti-infmamatory drugs. TASP0415914 has shown excellent results in cell based assays. It is orally available and has performed will in murine in vivo models. PI3Kgamma IC(50) 29nM, AKT IC(50) 294nM.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at +4°C.
References
Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase gamma inhibitor for the treatment of inflammatory diseases: Y. Oka, et al.; Bioorg. Med. Chem. 21, 7578 (2013)