Neobavaisoflavone
Product Code: AG-CN2-0498
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0498-M001 | 1 mg | £170.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
7-Hydroxy-3-(4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl)-4H-1-benzopyran-4-one; 3'-Prenyldaidzein
Appearance:
White to off-white solid.
CAS:
41060-15-5
EClass:
32160000
Form (Short):
solid
Handling Advice:
Keep cool and dry.Protect from light.
InChi:
InChI=1S/C20H18O4/c1-12(2)3-4-14-9-13(5-8-18(14)22)17-11-24-19-10-15(21)6-7-16(19)20(17)23/h3,5-11,21-22H,4H2,1-2H3
InChiKey:
OBGPEBYHGIUFBN-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 41060-15-5. Formula: C20H18O4. MW: 322.4. Isolated from Psoralea corylifolia sp. Antibiotic. Antibacterial and antifungal compound. Displays antibiotic activity against Gram-negative multidrug resistant bacteria. Anticancer compound. DNA polymerase inhibitor. Enhances TRAIL-induced apoptosis via inhibition of metastasis. Anti-inflammatory agent inhibiting IL-6-induced STAT3 activation and phosphorylation. Platelet aggregation inhibitor. Human carboxylesterase 1&2 and UDP-glucuronosyltransferase 1A1 inhibitor, enzymes important in drug metabolism. Antioxidant. Inhibits the production of nitric oxide (NO), reactive oxygen species (ROS) and reactive nitrogen species (RNS). Neuroprotective. Exerts protective effects against H2O2-induced neuronal cell damage. Shows osteogenic acitivty.
MDL:
MFCD00800660
Molecular Formula:
C20H18O4
Molecular Weight:
322.4
Package Type:
Vial
Product Description:
Antibiotic. Antibacterial and antifungal compound. Displays antibiotic activity against Gram-negative multidrug resistant bacteria. Anticancer compound. DNA polymerase inhibitor. Enhances TRAIL-induced apoptosis via inhibition of metastasis. Anti-inflammatory agent inhibiting IL-6-induced STAT3 activation and phosphorylation. Platelet aggregation inhibitor. Human carboxylesterase 1&2 and UDP-glucuronosyltransferase 1A1 inhibitor, enzymes important in drug metabolism. Antioxidant. Inhibits the production of nitric oxide (NO), reactive oxygen species (ROS) and reactive nitrogen species (RNS). Neuroprotective. Exerts protective effects against H2O2-induced neuronal cell damage. Shows osteogenic acitivty.
Purity:
>98% (HPLC)
SMILES:
OC1=CC=C(C(C(C2=CC=C(O)C(C/C=C(C)/C)=C2)=CO3)=O)C3=C1
Solubility Chemicals:
Soluble in DMSO, ethanol or methanol.
Source / Host:
Isolated from Psoralea corylifolia sp.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Prenylated isoflavanone from the roots of Erythrina sigmoidea: A.E. Nkengfack, et al.; Phytochemistry 36, 1047 (1994) | Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) | DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia: N.J. Sun, et al.; J. Nat. Prod. 61, 362 (1998) | Studies on the chemical constituents of Psoralea corylifolia L.: B. Ruan, et al.; J. Asian Nat. Prod. Res. 9, 41 (2007) | The combination of TRAIL and isoflavones enhances apoptosis in cancer cells: J. Bronikowska, et al.; Molecules 15, 2000 (2010) | Inhibition of inflammatory mediators by neobavaisoflavone in activated RAW264.7 macrophages: E. Szliszka, et al.; Molecules 16, 3701 (2011) | Neobavaisoflavone stimulates osteogenesis via p38-mediated up-regulation of transcription factors and osteoid genes expression in MC3T3-E1 cells: M.-J. Don, et al.; Phytomed. 19, 551, (2012) | Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation: S.W. Lee, et al.; Planta Med. 78, 903 (2012) | Neobavaisoflavone sensitizes apoptosis via the inhibition of metastasis in TRAIL-resistant human glioma U373MG cells: Y.J. Kim, et al.; Life Sci. 95, 101 (2014) | Activity of three cytotoxic isoflavonoids from Erythrina excelsa and Erythrina senegalensis (neobavaisoflavone, sigmoidin H and isoneorautenol) toward multi-factorial drug resistant cancer cells: V. Kuete, et al.; Phytomed. 21, 682 (2014) | Antibacterial activity of nineteen selected natural products against multi-drug resistant Gram-negative phenotypes: A.T. Mbaveng, et al.; SpringerPus 4, 823 (2015) | Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2: Y.G. Li, et al.; Fitoterapia 101, 99 (2015) | Identification and characterization of naturally occurring inhibitors against UDP-glucuronosyltransferase 1A1 in Fructus Psoraleae (Bu-gu-zhi): X.X. Wang, et al.; Toxicol. Appl. Pharmacol. 289, 70 (2015) | Quantitative analysis of Psoralea corylifolia L. and its neuroprotective and anti-neuroinflammatory effects in HT22 hippocampal cells and BV-2 microglia: Y.J. Kim, et al.; Molecules 21, e2076 (2016) | Inhibition behavior of fructus psoraleae?s ingredients towards human carboxylesterase 1 (hCES1): D.X. Sun, et al.; Xenobiotica 46, 503 (2016)