Colistin sulfate (Ph.Eur. Grade)
Product Code: AG-CN2-0512
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0512-M100 | 100 mg | £40.00 |
Quantity:
| AG-CN2-0512-G001 | 1 g | £80.00 |
Quantity:
| AG-CN2-0512-G005 | 5 g | £290.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
Short term storage: +4°C Long term storage: +4°C
Documents
Further Information
Alternate Names/Synonyms:
Polymyxin E; Belcomycin; Colimycin
Appearance:
White to off-white powder.
Biological Activity:
Potency (dry basis) >19000U/mg
CAS:
1264-72-8
Class:
6.1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS06
Handling Advice:
Keep cool and dry.
Hazards:
H301
InChi:
InChI=1S/C52H98N16O13/c1-9-29(6)11-10-12-40(71)59-32(13-19-53)47(76)68-42(31(8)70)52(81)64-35(16-22-56)44(73)63-37-18-24-58-51(80)41(30(7)69)67-48(77)36(17-23-57)61-43(72)33(14-20-54)62-49(78)38(25-27(2)3)66-50(79)39(26-28(4)5)65-45(74)34(15-21-55)60-46(37)75/h27-39,41-42,69-70H,9-26,53-57H2,1-8H3,(H,58,80)(H,59,71)(H,60,75)(H,61,72)(H,62,78)(H,63,73)(H,64,81)(H,65,74)(H,66,79)(H,67,77)(H,68,76)/t29?,30-,31-,32+,33+,34+,35+,36+,37+,38+,39-,41+,42+/m1/s1
InChiKey:
YKQOSKADJPQZHB-QNPLFGSASA-N
Long Description:
Chemical. CAS: 1264-72-8. Formula: 2(C52H98N16O13) . 5(H2SO4) (unspec.). MW: 2801.7. Isolated from Bacillus polymyxa. Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections.
MDL:
MFCD27976775
Molecular Formula:
2(C52H98N16O13) . 5(H2SO4) (unspec.)
Molecular Weight:
2801.7
Package Type:
Plastic Vial
PG:
III
Precautions:
P301, P310
Product Description:
Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections.
Purity:
>77% (Mixture, primarly Polymyxin E1 and Polymyxin E2).
Signal word:
Danger
SMILES:
CCC(C)CCCC(N[C@@H](CCN)C(N[C@@H]([C@@H](C)O)C(N[C@@H](CCN)C(N[C@H](C(N[C@@H](CCN)C1=O)=O)CCNC([C@@H](NC([C@@H](NC([C@H](CCN)NC([C@@H](NC([C@H](N1)CC(C)C)=O)CC(C)C)=O)=O)CCN)=O)[C@@H](C)O)=O)=O)=O)=O)=O.O=S(O)(O)=O
Solubility Chemicals:
Soluble in water (50mg/ml).
Source / Host:
Isolated from Bacillus polymyxa.
Transportation:
Excepted Quantity
UN Nummer:
UN3462
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
Antimicrobial drugs, microorganisms, and phagocytes: P.J. van den Broek; Rev. Infect. Dis. 11, 213 (1989) (Review) | Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria: M.E. Evans, et al.; Ann. Pharmacother. 33, 960 (1999) (Review) | The clinical use of colistin in patients with cystic fibrosis: P. Beringer; Curr. Opin. Pulm. Med. 7, 434 (2001) (Review) | Update on antimicrobial agents: new indications of older agents: T.R. Pasquale & J.S. Tan; Expert Opin. Pharmacother. 6, 1681 (2005) (Review) | Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections: J. Li, et al.; Lancet Infect. Dis. 6, 589 (2006) (Review) | Polymyxin B: similarities to and differences from colistin (polymyxin E): A. Kwa, et al.; Expert Rev. Anti. Infect. Ther. 5, 811 (2007) (Review) | Colistin in the 21st century: R.L. Nation & J. Li; Curr. Opin. Infect. Dis. 22, 535 (2009) (Review) | New information about the polymyxin/colistin class of antibiotics: J. Molina, et al.; Expert Opin. Pharmacother. 10, 2811 (2009) (Review) | Colistin: new lessons on an old antibiotic: D. Yahav, et al.; Clin. Microbiol. Infect. 18, 18 (2012) (Review) | A pulmonary mucus surrogate for investigating antibiotic permeation and activity against Pseudomonas aeruginosa biofilms: S. Frisch, et al.; J. Antimicrob. Chemother. 76, 1472 (2021)
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