ONX 0914

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis: T. Muchamuel, et al.; Nat. Med. 15, 781 (2009) | Prevention of experimental colitis by a selective inhibitor of the immunoproteasome: M. Basler, et al.; J. Immunol. 185, 634 (2010) | Immunoproteasome-specific inhibitors and their application: M. Basler & M. Groettrup; Methods Mol. Biol. 832, 391 (2012) | Prophylactic and therapeutic efficacies of a selective inhibitor of the immunoproteasome for Hashimoto's thyroiditis, but not for Graves' hyperthyroidism, in mice: Y. Nagayama, et al.; Clin. Exp. Immunol. 168, 268 (2012) | Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Th1 and Th17 but enhances regulatory T cell differentiation: K.W. Kalim, et al.; J. Immunol. 189, 4182 (2012) | Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis: M. Basler, et al.; EMBO Mol. Med. 6, 226 (2014) | Interferon-gamma-induced upregulation of immunoproteasome subunit assembly overcomes bortezomib resistance in human hematological cell lines: D. Niewerth, et al.; J. Hematol. Oncol. 7, 7 (2014) | Bortezomib-resistant mutant proteasomes: structural and biochemical evaluation with carfilzomib and ONX 0914: E.M. Huber, et al.; Structure 23, 407 (2015) | Inhibition of the Immunoproteasome Subunit LMP7 with ONX 0914 Ameliorates Graft-versus-Host Disease in an MHC-Matched Minor Histocompatibility Antigen-Disparate Murine Model: J. Zilberberg, et al.; Biol. Blood Marrow Transplant 21, 1555 (2015) | PR-957, a selective inhibitor of immunoproteasome subunit low-MW polypeptide 7, attenuates experimental autoimmune neuritis by suppressing Th17-cell differentiation and regulating cytokine production: H. Liu, et al.; FASEB J. 31, 1756 (2017) | Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice: J. Koerner, et al.; Oncotarget (Epub ahead of print) (2017)