VISTA [B7-H5] (human) (rec.) (His)
| Code | Size | Price |
|---|
| AG-40B-0177-C010 | 10 ug | £140.00 |
Quantity:
| AG-40B-0177-3010 | 3 x 10 ug | £270.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Shipping:
Blue Ice
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
V-type Immunoglobulin Domain-containing Suppressor of T Cell Activation; Platelet Receptor Gi24; Stress-induced Secreted Protein-1; Sisp-1; V-set Domain-containing Immunoregulatory Receptor
Concentration:
0.1mg/ml after reconstitution.
EClass:
32160000
Endotoxin:
<0.01EU/µg purified protein (LAL test).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. The extracellular domain of human VISTA (B7-H5) (aa 33-194) is fused at the C-terminus to a His-tag. Source: HEK 293 cells. Endotoxin: <0.01EU/µg. Lyophilized. Contains PBS. Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on antigen presenting cells (APC) delivers negative signaling to T cells via a yet-to-identify binding partner on T cells.
Molecular Weight:
~30-40kDa (SDS-PAGE)
NCBI, Uniprot Number:
Q9H7M9
Package Type:
Plastic Vial
Product Description:
Human VISTA is a 55 to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on antigen presenting cells (APC) delivers negative signaling to T cells via a yet-to-identify binding partner on T cells.
Purity:
>95% (SDS-PAGE)
Sequence:
The extracellular domain of human VISTA (B7-H5) (aa 33-194) is fused at the C-terminus to a His-tag.
Source / Host:
HEK 293 cells
TAGs:
His
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.