AIMP1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-820-0.1mg | 0.1mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
AIMP1,EMAP2,EMAPII,HLD3,SCYE1,p43,EMAP-2,EMAP-II,AIMP-1
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) is also known as multisynthase complex auxiliary component p43 and endothelial monocyte-activating polypeptide II (EMAP-II). AIMP1 is a cytokine that may be induced by apoptosis and is also released from professional antigen-presenting cells such as dendritic cells. The release of AIMP1 renders the tumor-associated vasculature sensitive to tumor necrosis factor. Furthermore, AIMP1 binds tRNA and stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. This protein possesses inflammatory cytokine activity. Also, AIMP1 negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation.
Background References:
- Barnett G., et al., 2000, Cancer Res. 60:2850-2857.
- Park S.G., et al., 1999, J. Biol. Chem. 274:16673-16676.
- Tandle A.T., et al., 2009, Exp. Cell Res. 315:1850-1859.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
9255
NCBI Official Name:
Small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)
NCBI Official Symbol:
AIMP1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
35.2 kDa
Protein Accession #:
AAH14051
Purity:
>95% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
NP_004748.2