Hydroxytyrosol
| Code | Size | Price |
|---|
| CDX-H0155-M025 | 25 mg | £84.00 |
Quantity:
| CDX-H0155-M100 | 100 mg | £194.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Documents
Further Information
Alternate Names/Synonyms:
3-Hydroxytyrosol; 2-(3,4-Dihydroxyphenyl)ethanol; 3,4-Dihydroxyphenethyl alcohol; DOPET; 3,4-DHPEA; Ba2774
Appearance:
Yellow liquid.
CAS:
10597-60-1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C8H10O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,9-11H,3-4H2
InChiKey:
JUUBCHWRXWPFFH-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 10597-60-1. Formula: C8H10O3. MW: 154.16. Synthetic. Phenolic component of olive oil. Metabolite of oleuropein. Antioxidant that inhibits both 12- and 5-lipoxygenase (LO) activity. The IC50 values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.2 and 13µM, respectively. It does not inhibit, and may actually enhance, COX activity. Protects LDL from both biological and chemical oxidation, suggesting a potential mechanism for the protective effects of olive oil against atherosclerosis. Inhibits the rate of cancer cell proliferation and induces cancer cell apoptosis. Also described to induce growth arrest and apoptosis in human colon carcinoma HT-29 cells through activation of the serine/threonine protein phosphatase 2A. Protects beta-Cells from amylin amyloid-Induced cytotoxicity.
MDL:
MFCD01320529
Molecular Formula:
C8H10O3
Molecular Weight:
154.16
Package Type:
Vial
Precautions:
P261, P305+P351+P338
Product Description:
Phenolic component of olive oil. Metabolite of oleuropein. Antioxidant that inhibits both 12- and 5-lipoxygenase (LO) activity. The IC50 values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.2 and 13µM, respectively. It does not inhibit, and may actually enhance, COX activity. Protects LDL from both biological and chemical oxidation, suggesting a potential mechanism for the protective effects of olive oil against atherosclerosis. Inhibits the rate of cancer cell proliferation and induces cancer cell apoptosis. Also described to induce growth arrest and apoptosis in human colon carcinoma HT-29 cells through activation of the serine/threonine protein phosphatase 2A. Protects beta-Cells from amylin amyloid-Induced cytotoxicity.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
OC1=CC=C(CCO)C=C1O
Solubility Chemicals:
Soluble in DMSO.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) N. Kohyama, et al.; Biosci. Biotechnol. Biochem. 61, 347 (1997) | (2) P. Grignaffini, et al.; Lancet 343, 1296 (1994) | (3) C. Manna, et al.; J. Nutr. 127, 286 (1997) | (4) C.A. Palmerini, et al.; J. Nutr. Biochem. 16, 109 (2005) | (5) C. Guichard, et al.; Carcinogenesis 27, 1812 (2006) | (6) L. Wu, et al.; Biochemistry 56, 5035 (2017) | Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health: A. Karkovic Markovic, et al.; Molecules 24, E2001 (2019)