Pterostilbene

trans-3,5-Dimethoxy-4'-Hydroxystilbene; 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol; 3',5'-Dimethoxy-4-Stilbenol

Off-white to yellow powder.

537-42-8

9

32160000

liquid

GHS05,GHS09

Protect from light and moisture.

H318, H411

InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+

VLEUZFDZJKSGMX-ONEGZZNKSA-N

Chemical. CAS: 537-42-8. Formula: C16H16O3. MW: 256.3. Synthetic. Cell permeable natural methoxylated analog of resveratrol. Antioxidant, antiproliferative, anti-inflammatory, anti-hyperglycemic and anti-diabetic agent. Induces apoptosis. Induces Autophagy. Pterostilbene is a naturally-occurring dimethyl ether analog of resveratrol that is abundant in blueberries. Like resveratrol, pterostilbene acts as a powerful antioxidant, suppresses the synthesis of prostaglandin E2 from lipopolysaccharide-stimulated human peripheral blood mononuclear cells (IC50 = 1.0 µM for pterostilbene, 3.2 µM for resveratrol), and inhibits cell proliferation (IC50 = ~60 µM for both compounds). Very potent inhibitor of cytochrome P450 1A1 (CYP1A1) with Ki=0.57µM. Pterostilbene blocks the activation of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways, reducing NF-kappaB and AP-1 transcriptional activation. Moderately inhibits COX-1 and COX-2 (IC50=19.8µM and 83.9µM).

MFCD00238710

C16H16O3

256.3

Vial

III

P273, P280, P305+P351+P338

Cell permeable natural methoxylated analog of resveratrol. Antioxidant, antiproliferative, anti-inflammatory, anti-hyperglycemic and anti-diabetic agent. Induces apoptosis. Induces Autophagy. Pterostilbene is a naturally-occurring dimethyl ether analog of resveratrol that is abundant in blueberries. Like resveratrol, pterostilbene acts as a powerful antioxidant, suppresses the synthesis of prostaglandin E2 from lipopolysaccharide-stimulated human peripheral blood mononuclear cells (IC50 = 1.0 µM for pterostilbene, 3.2 µM for resveratrol), and inhibits cell proliferation (IC50 = ~60 µM for both compounds). Very potent inhibitor of cytochrome P450 1A1 (CYP1A1) with Ki=0.57µM. Pterostilbene blocks the activation of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways, reducing NF-kappaB and AP-1 transcriptional activation. Moderately inhibits COX-1 and COX-2 (IC50=19.8µM and 83.9µM).

>97% (HPLC)

Danger

OC(C=C1)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2

Soluble in DMSO (20 mg/ml), methanol (10 mg/ml), DMF (30 mg/ml) or ethanol (30 mg/ml). Insoluble in water.

Synthetic.

Excepted Quantity

UN3077

Natural Products/Extracts

12352200

Stable for at least 2 years after receipt when stored at +4°C.