Orthoformimycin
Product Code: AG-CN2-0314
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0314-C500 | 500 ug | £250.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Orthoformimycin A/B Mixture
Appearance:
Beige powder.
CAS:
1450896-99-7 [A]1450897-02-5 [B]
EClass:
32160000
Form (Short):
solid
Handling Advice:
Keep cool and dry.Protect from light.Protect from light when in solution.
InChi:
InChI=1S/C25H37N3O10/c1-12(10-13-6-8-14(9-7-13)27(2)3)23(33)26-16-17(28(4)5)21-22(19(32)18(16)31)38-25(37-21)36-20(24(34)35)15(30)11-29/h6-10,15-22,25,29-32H,11H2,1-5H3,(H,26,33)(H,34,35)/b12-10+
InChiKey:
LPVLOXICDYAAJH-ZRDIBKRKSA-N
Long Description:
Chemical. CAS: 1450896-99-7 [A], 1450897-02-5 [B]. Formula: C25H37N3O10. MW: 539.6. Isolated from Streptomyces sp. Cinnamoyl aminoglycoside antibiotic. Protein synthesis inhibitor in vitro. Selective inhibitor of bacterial translation elongation, through binding to the 50S subunit. Inhibits EF-G-dependent mRNA translocation but not translocation of the aminoacyl-tRNA. Moderate antibacterial compound, in both Gram-positive and Gram-negative bacteria.
MDL:
N/A
Molecular Formula:
C25H37N3O10
Molecular Weight:
539.6
Package Type:
Vial
Product Description:
Cinnamoyl aminoglycoside antibiotic. Protein synthesis inhibitor in vitro. Selective inhibitor of bacterial translation elongation, through binding to the 50S subunit. Inhibits EF-G-dependent mRNA translocation but not translocation of the aminoacyl-tRNA. Moderate antibacterial compound in both Gram-positive and Gram-negative bacteria.
Purity:
>80% (HPLC, for A/B)
SMILES:
O=C(/C(C)=C/C1=CC=C(C=C1)N(C)C)NC2C(C(C3OC(OC(C(CO)O)C(O)=O)OC3C2N(C)C)O)O
Solubility Chemicals:
Soluble in DMSO or water.
Source / Host:
Isolated from Streptomyces sp.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Orthoformimycin, a selective inhibitor of bacterial translation elongation from Streptomyces containing an unusual orthoformate: S.I. Maffioli, et al.; ACS Chem. Biol. 8, 1939 (2013) | Discovering new bioactive molecules from microbial sources: P. Monciardini, et al.; Microb. Biotechnol. 7, 209 (2014) (Review)