Rifamycin AF-K91725
Product Code: AG-CN2-0327
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0327-M010 | 10 mg | £120.00 |
Quantity:
| AG-CN2-0327-M050 | 50 mg | £450.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
3-[(2-Methyl-2-phenylhydrazono)methyl]-rifamycin; NCI 145-624; NSC 145624
Appearance:
Red powder.
CAS:
13292-38-1
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Protect from light.Protect from light when in solution.
InChi:
InChI=1S/C45H55N3O12/c1-22-15-14-16-23(2)44(56)47-35-30(21-46-48(9)29-17-12-11-13-18-29)39(53)32-33(40(35)54)38(52)27(6)42-34(32)43(55)45(8,60-42)58-20-19-31(57-10)24(3)41(59-28(7)49)26(5)37(51)25(4)36(22)50/h11-22,24-26,31,36-37,41,50-54H,1-10H3,(H,47,56)/b15-14+,20-19+,23-16-,46-21+/t22-,24+,25+,26+,31?,36-,37+,41+,45-/m0/s1
InChiKey:
RTWBQHLEWMZULD-WHUWOYLUSA-N
Long Description:
Chemical. CAS: 13292-38-1. Formula: C45H55N3O12. MW: 829.9. Semisynthetic. Ansamycin antibiotic. Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP). Effective against mycobacteria, and are therefore used in research of tuberculosis, leprosy and mycobacterium avium complex (MAC) infections.
Molecular Formula:
C45H55N3O12
Molecular Weight:
829.9
Package Type:
Vial
Product Description:
Ansamycin antibiotic. Selective inhibitor of bacterial DNA-dependent RNA polymerase (RNAP). Effective against mycobacteria and therefore used in research of tuberculosis, leprosy and Mycobacterium avium complex (MAC) infections.
Purity:
>90% (HPLC)
SMILES:
OC1=C(NC(/C(C)=CC=C[C@H](C)[C@H](O)[C@@H](C)[C@H]([C@H]2C)O)=O)C(/C=N/N(C)C3=CC=CC=C3)=C(O)C4=C5C(O[C@@](O/C=C/[C@H](OC)[C@H]([C@H]2OC(C)=O)C)(C)C5=O)=C(C)C(O)=C41
Solubility Chemicals:
Soluble in DMSO, aqueous acetonitrile or ethanol.
Source / Host:
Semisynthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Rifamycin antibiotics: inhibitors of Rauscher murine leukemia virus reverse transcriptase and of purified DNA polymerases from human normal and leukemic lymphoblasts: S.S. Yang, et al.; J. Natl. Cancer Inst. 49, 7 (1972) | Rifamycin Derivatives Strongly Inhibiting RNA>DNA Polymerase (Reverse Transcriptase) of Murine Sarcoma Viruses: C. Gurgo, et al.; J. Natl. Cancer Inst. 49, 61 (1972) | Hydrazones of 3-formylrifamycin SV. III. N-(Mono and di)substituted hydrazone derivatives. Synthesis, antibacterial activity, and other biological properties: R. Cricchio, et al.; Farmaco Sci. 30, 704 (1975) | QSAR Modeling of Antimycobacterial Activity and Activity Against Other Bacteria of 3-Formyl Rifamycin SV Derivatives: D. Dimov, et al.; Quant. Struct.-Act. Relat. 20, 298 (2001)
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