IL-2 (human) (rec.) (untagged)
| Code | Size | Price |
|---|
| CHI-HR-20602-C010 | 10 ug | £165.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: E.coli
Regulatory Status: RUO
Target Species: Human
Storage:
-80°C
Further Information
Alternate Names/Synonyms:
Interleukin-2; Aldesleukin
Biological Activity:
Measured in a cell proliferation assay using CTLL2 cells. The ED50 for this effect is typically 0.35-1.4ng/ml.
EClass:
32160000
Endotoxin:
<0.01EU/µg protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Lyophilized from sterile 0.1% TFA, 70% acetonitrile.
Handling Advice:
Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
Long Description:
Protein. The extracellular domain of human IL-2 (aa 21-153) with a N-terminal Met. Source: E. coli. Endotoxin content: <0.01EU/µg protein (LAL test; Lonza). Lyophilized from sterile 0.1% TFA, 70% acetonitrile. Purity: >95% (SDS-PAGE). Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
Molecular Weight:
~14kDa (SDS-PAGE)
NCBI, Uniprot Number:
NP_000577.2
Package Type:
Plastic Vial
Product Description:
Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
Purity:
>95% (SDS-PAGE)
Sequence:
The extracellular domain of human IL-2 (aa 21-153) with a N-terminal Met.
Source / Host:
E. coli
TAGs:
no TAG
Transportation:
Non-hazardous
UNSPSC Category:
Interleukins
UNSPSC Number:
41116127
Use & Stability:
Stable for at least 1 year after receipt when stored at -80°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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