BeCytes Biotechnologies (previously known as Cytes Technologies) - Liver Cells, Tissue Procurement and CRO Services Provided in the UK & Europe by Caltag Medsystems

BeCytes Biotechnologies

BeCytes Biotechnologies is a biotechnological company that offers products and services (CRO) based on tissue procurement, cell isolation and cell solutions for in vitro models for research purposes. ​

Their main focus is the isolation and full characterisation of primary human and animal hepatic and skin cells, as well as providing different tissue explants (pathological and healthy donors).

BeCytes Biotechnologies offers an extensive portfolio of cryopreserved human and animal liver cells, including plateable and suspension hepatocytes, stellates, Kupffers, liver sinusoidal endothelial cells and sub-cellular liver fractions.

BeCytes have built a reputation for providing researchers with high-quality products and services, achieved through detailed quality management systems and validated processes. These processes focus on quality, high cell viability and safety in compliance with ethical and regulatory international standards.

Primary Human Hepatocytes

BeCytes Biotechnologies hold a large stock of hepatocytes and perform new isolations every month of human hepatocytes available in 3 different formats: cryopreserved plated, cryopreserved in suspension, cryopreserved plateable.

Hepatocytes in suspension are cultured in suspension and mostly, they are not able to form a confluent monolayer on collagen-coated plates which is advantageous for certain research scenarios.

The most accurate representation of in vivo cellular function and characteristics can be achieved with plateable hepatocytes. BeCytes Biotechnologies cryopreserved human plateable hepatocytes are qualified by their ability to maintain a confluent monolayer (85% confluency) for at least five days.

Their human hepatocytes maintain morphology and function over long periods, and are supplied with:

  • Demographic and clinical donor profile
  • Viability and morphology assessment
  • Culture protocols

BeCytes Biotechnologies also provides the optimal media for the culture of these human hepatocytes.

See All Primary Human Hepatocytes     See Media for Human Hepatocytes

Primary Animal Hepatocytes and Sub-Cellular Liver Fractions

BeCytes Biotechnologies also provides cryopreserved animal hepatocytes which are produced with the same methodology used in the isolation of human hepatocytes.

Primary Animal Hepatocytes and Sub-cellular liver fractions (Microsomes, Cytosol and S9 fraction) are model systems often used for a variety of in vitro screenings and analyses before clinical studies in human and animal health & environmental toxicology.

While animal hepatocytes in suspension are important for short-term metabolism studies, plated animal hepatocytes are perfect for the studies of long-term metabolism or evaluation of drug candidates to investigate drug-drug interactions.

BeCytes' dog beagle, monkey cynomolgus, rat and minipig hepatocytes are model systems frequently used in vitro screening methods. They closely match the physiology in vivo and contribute to the identification of safety issues early in the drug development pipeline.

BeCytes Biotechnologies has hepatocytes from a range of species available:

See All Primary Animal Hepatocytes     See Media for Animal Hepatocytes

Sub-Cellular Liver Fractions:

BeCytes Biotechnologies offers a selection of sub-cellular liver fractions: Microsomes, Cytosol and S9, from a variety of species:

See All Sub-Cellular Liver Fractions

Hepatic Non-Parenchymal Cells (NPCs)

Hepatic non-parenchymal cells (NPCs) represent about 30% of the liver and are specialised cells which interact with hepatocytes. NPCs present organotypic hepatocyte-NPC interactions via direct contact or paracrine signalling and forming a functional hepatic unit.

Among their many functions, NPCs play an important role for liver regeneration as well as recovery from inflammatory liver injury and scaring.

Advanced liver models, including those with in vivo-like environments and liver co-cultures, are essential for accurate predictive responses in studying liver physiology/pathology and conducting drug screenings, offering increased sensitivity and the ability to manipulate various conditions and analyse multiple parameters.

BeCytes Biotechnologies offers:

BeCytes Biotechnologies also provides the optimal media for the culture of these NPCs.

See All Hepatic Non-Parenchymal Cells     See Media for NPCs

Tissue Procurement

BeCytes offers a custom tissue procurement service to acquire samples tailored to unique research requirements. BeCytes Biotechnologies has created a platform capable of coordinating the donation of human tissues and cells for biomedical research purposes, encompassing strong collaborations with national and international procurement centres, biobanks and hospitals that allow them to provide a wide range of tissue samples.

Tissue samples available include skin, lung, intestine, pancreas, kidney, brain, ovarian, liver, and rectal.

Benefits of BeCytes custom tissue procurement:

  • Extensive network of biobanks, hospitals, OPOS, etc to provide a wide range of healthy and pathological tissues.
  • Tissue samples available in multiple formats, such as fresh, frozen, or formalin-fixed paraffin-embedded (FFPE).
  • Tailored procurement and processing of biospecimens according to the conditions needed for research.
  • Access to first-hand information about the donor post medical record, where the most relevant data is reflected.

Tissue Procurement Manual     Contact us for more details

CRO Services

BeCytes offer further customised research services. Please contact us for details.

Contact us for details

Blog posts

Organoids vs Spheroids: 3 important differences

A panel of experts has revisited the concept of an organoid & introduced an intuitive classification system & terminology for describing 3D structures.


Exploring the pros and cons of diverse tissue formats for research

BeCytes Biotechnologies can provide a wide range of tissue samples in either Formalin-fixed paraffin-embedded or Fresh Frozen format.


How can Liver Sinusoidal Endothelial Cells help you upgrade your research?

LSECs have significant research uses in liver regeneration studies, in vitro toxicity testing and the clearance of pathogens and macromolecules.


Are you including Kupffer Cells in your hepatic models?

Doubting whether to include immune cells in your model? Including Kuppfer cells allows you to better study iDILI & improve hepatocyte functionality.


New nomenclature for liver disease (NASH and NAFLD vs MASH and MASLD)

The liver diseases of nonalcoholic fatty liver disease (NAFLD) & nonalcoholic steatohepatitis (NASH) have changed names by a modified Delphi process.


Tips to Work with Primary Hepatocytes

To obtain the best results, BeCytes Biotechnologies has outlined essential practices for working with hepatocytes, from thawing to keeping them in culture.


BeCytes Biotechnologies: Liver Cells for Research - Animal Hepatocytes

BeCytes Biotechnologies offers a range of animal hepatocytes for research purposes.



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