IFNAR1 Antibody / Interferon alpha receptor 1

Western blot: 1:500-1:2000

Optimal dilution of the IFNAR1 antibody should be determined by the researcher.

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). [UniProt]

Purified

Antibody in PBS with 0.02% sodium azide and 50% glycerol

A synthetic peptide from human Interferon Receptor alpha was used as the immunogen for the IFNAR1 antibody.

This IFNAR1 antibody is available for research use only.

Cell membrane, Cytoplasm

Protein A affinity

Human

P17181