CD106 Antibody [1.G11B1] (FITC)

VCAM-1, INCAM-110, vascular cell adhesion molecule-1

CD106 Antibody [1.G11B1] for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.

CD106, also known as INCAM-110, is a 110 kDa vascular adhesion cell adhesion molecule-1 (VCAM-1) that is member of the immunoglobulin superfamily. CD106 is expressed predominantly on cytokine-activated vascular endothelium but has also been identified on interfollicular dendritic cells, some macrophages, and bone marrow stromal cells. Endothelial CD106 binds the integrins alpha4beta1 (CD49d/CD29, VLA-4) and alpha4beta7 and contributes to extravasation of lymphocytes, monocytes, basophils, and eosinophils (but not neutrophils) from blood vessels, particularly at sites of inflammation. Unlike the beta2 integrins, the CD106-VLA-4 interaction can mediate both the initial tethering and rolling of lymphocytes on endothelium as well as their subsequent arrest and firm adhesion. CD106 expressed on non-vascular tissues has been implicated in the interaction of hematopoietic progenitors with bone marrow stromal cells, B cell binding to follicular dendritic cells, costimulation of T cells, and embryonic development. The monoclonal antibody 1.G11B1 inhibits in vitro binding of lymphocytes and monocytes to VCAM-1 on stimulated endothelium.

Supplied in PBS/NaN3

Lot specific

FITC

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

7412

Vascular cell adhesion protein 1

VCAM1

Homo sapiens

Liquid

P19320

Cancer,Neuroscience,Signal Transduction

CD106

P19320

Optimal dilutions for each application to be determined by the researcher.