ProSci

CD107b Antibody [H4B4]

Product Code:
 
PSI-99-603
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
[H4B4]
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Shipping:
 
blue ice
Storage:
 
Store vial at 2-8˚C
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Human T lymphocyte cell line Jurkat was intracellularly stained with Mouse Anti-Human CD107b-UNLB (Cat. No. 99-603) followed by Goat Anti-Mouse IgG1, Human ads-FITC .
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MYH1 siRNA transfected MCF7 cells were stained with Mouse Anti-Human CD107b-UNLB (Cat. No. 99-603) followed by a secondary antibody. Image from Groth-Pedersen L, Aits S, Corcelle-Termeau E, Petersen NH, Nylandsted J, J??ttel? M. Identification of cytoskeleton- associated proteins essential for lysosomal stability and survival of human cancer cells. PLoS One. 2012;7:e45381. Figure 2(c)
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Human T lymphocyte cell line Jurkat was intracellularly stained with Mouse Anti-Human CD107b-UNLB (Cat. No. 99-603) followed by Goat Anti-Mouse IgG1, Human ads-FITC .
MYH1 siRNA transfected MCF7 cells were stained with Mouse Anti-Human CD107b-UNLB (Cat. No. 99-603) followed by a secondary antibody. Image from Groth-Pedersen L, Aits S, Corcelle-Termeau E, Petersen NH, Nylandsted J, J??ttel? M. Identification of cytoskeleton- associated proteins essential for lysosomal stability and survival of human cancer cells. PLoS One. 2012;7:e45381. Figure 2(c)

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PSI-99-603-0.1mg0.1mg£373.00
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Further Information

Additional Names:
LAMP-2, lysosome-associated membrane protein 2
Application Note:
CD107b Antibody [H4B4] for use in flow cytometry, immunohistochemistry / immunocytochemistry, electron microscopy, western blotting, immunoprecipitation, and purification assays.
Background:
CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains and is a ligand for E-selectin-mediated cell adhesion. CD107b is expressed in lysosomal/endosomal membranes and on the surface of activated platelets and some tumor cell lines including U937 and KG1a. LAMP-2 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Human adherent peripheral blood cells
NCBI Gene ID #:
3920
NCBI Official Name:
Lysosome-associated membrane glycoprotein 2
NCBI Official Symbol:
LAMP2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
P13473
Research Area:
Immunology,Obesity,Signal Transduction
SPECIFICITY:
CD107b
Swissprot #:
P13473
User NOte:
Optimal dilutions for each application to be determined by the researcher.