ProSci

DR5 Antibody

Product Code:
 
PSI-99-188
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Blocking
  • Immunocytochemistry (ICC)
  • Immunohistochemistry- Frozen Section (IHC-F)
  • Immunoprecipitation (IP)
Shipping:
 
blue ice
Storage:
 
Store vial at 2-8˚C
1 / 3
Human T lymphocyte cell line Jurkat was stained with Rabbit Anti-Human DR5-UNLB (Cat. No. 99-188) followed by Mouse Anti-Rabbit IgG-PE .
2 / 3
Total cell lysates from Jurkat cells were resolved by electrophoresis, transferred to PVDF membrane, and probed with Rabbit Anti-Human DR5-UNLB (Cat. No. 99-188). Proteins were visualized using Goat Anti-Rabbit IgG(H+L), Mouse/Human ads-HRP secondary antibody and chemiluminescent detection.
3 / 3
Human hepatocellular carcinoma cell line Hep G2 was stained with Rabbit Anti-Human DR5-UNLB (Cat. No. 99-188; right) and Rabbit IgG-UNLB (Cat. No. 0111-01; left) followed by Donkey Anti-Rabbit IgG(H+L), Mouse/Rat/Human SP ads-BIOT (Cat. No. 6440-08, Streptavidin-CY3 , and DAPI.
❮❯

Human T lymphocyte cell line Jurkat was stained with Rabbit Anti-Human DR5-UNLB (Cat. No. 99-188) followed by Mouse Anti-Rabbit IgG-PE .
Total cell lysates from Jurkat cells were resolved by electrophoresis, transferred to PVDF membrane, and probed with Rabbit Anti-Human DR5-UNLB (Cat. No. 99-188). Proteins were visualized using Goat Anti-Rabbit IgG(H+L), Mouse/Human ads-HRP secondary antibody and chemiluminescent detection.
Human hepatocellular carcinoma cell line Hep G2 was stained with Rabbit Anti-Human DR5-UNLB (Cat. No. 99-188; right) and Rabbit IgG-UNLB (Cat. No. 0111-01; left) followed by Donkey Anti-Rabbit IgG(H+L), Mouse/Rat/Human SP ads-BIOT (Cat. No. 6440-08, Streptavidin-CY3 , and DAPI.

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PSI-99-188-0.1mg0.1mg£597.00
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Further Information

Application Note:
DR5 Antibody for use in flow cytometry, immunocytochemistry, and western blotting assays.
Background:
DR5, also known as TRAIL-R2, TRICK2 and KILLER, is a widely expressed type I membrane member of the tumor necrosis (TNF) receptor family. Members of this family contain multiple cysteine-rich repeats in their extracellular domain and while the cytoplasmic region is less conserved, they do contain an intracellular 80 amino acid motif known as the ?death domain? (DD). DR5 is a receptor for the cytotoxic ligand TRAIL which induces apoptosis and it is the cytoplasmic DD that is responsible for transducing the death process. DR5 has also been shown to activate NF-?B.
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant DR5
Physical State:
Liquid
Research Area:
Cancer,Signal Transduction,Immunology
SPECIFICITY:
DR5
User NOte:
Optimal dilutions for each application to be determined by the researcher.