ProSci

NKX2.2 Antibody [NX2/1523]

Product Code:
 
PSI-33-721
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
NX2/1523
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
Shipping:
 
blue ice
Storage:
 
Aliquot and Store at -20C. Avoid freez-thaw cycles.
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IHC testing of FFPE Ewings sarcoma with NKX2.2 antibody (clone NX2/1523). HIER: steam sections in 10mM citrate buffer, pH 6.0, for 10-20 min.
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IHC testing of FFPE Ewings sarcoma with NKX2.2 antibody (clone NX2/1523). HIER: steam sections in 10mM citrate buffer, pH 6.0, for 10-20 min.

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PSI-33-721-100ug100ug£765.00
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Further Information

Additional Names:
NKX2-2 Antibody: NKX2B, NKX2.2, NKX2B, Homeobox protein NK-2 homolog B
Application Note:
Flow Cytometry: 0.5-1ug/10e6 cells in 0.1ml

IF: 1-2 ug/ml

IHC (FFPE): 1-2 ug/ml for 30 minutes at RT

Titering of the NKX2.2 antibody may be required for optimal performance.
Background:
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.2 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A human partial recombinant protein corresponding to amino acids 1-119 was used as the immunogen for this NKX2.2 antibody.
NCBI Gene ID #:
4821
NCBI Official Name:
NK2 homeobox 2
NCBI Official Symbol:
NKX2-2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein G affinity chromatography
Research Area:
Stem Cell
Swissprot #:
O95096
User NOte:
Optimal dilutions for each application to be determined by the researcher