ProSci

IKKb Antibody [IKB355]

Product Code:
 
PSI-33-004
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
IKB355
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Shipping:
 
blue ice
Storage:
 
Aliquot and Store at -20C. Avoid freez-thaw cycles.
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Western blot testing of human samples with IKKb antibody IKB355 at 2ug/ml.
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Western blot testing of human samples with IKKb antibody IKB355 at 2ug/ml.

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CodeSizePrice
PSI-33-004-100ug100ug£662.00
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Further Information

Additional Names:
IKK beta Antibody: IKK2, IKKB, IMD15, NFKBIKB, IKK-beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, I-kappa-B-kinase beta
Application Note:
Western blot: 2-4 ug/ml

Provided assay concentrations are suggestions only, IKKb antibody titration may be required for optimal results.
Background:
NF-kB is sequestered in the cytoplasm by IkBa, unable to translocate to the nucleus. IkB is part of the canonical pathway for NF-kB activation. IKKb is part of the IkB kinase complex, along with a second catalytic subunit, IKKa, and a regulatory subunit, IKKg. Along with IKKa, IKKb phosphorylates IkBa leading to its degradation and release of inhibition of NF-kB. The RELA subunit of active NF-kB is then free to enter the nucleus and initiate a number of signaling cascades.
Buffer:
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration:
0.5 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A recombinant protein fragment of IKKb was used as the immunogen for this antibody.
NCBI Gene ID #:
3551
NCBI Official Name:
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
NCBI Official Symbol:
IKBKB
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Protein G purified antibody
Research Area:
Signal Transduction
Swissprot #:
O14920
User NOte:
Optimal dilutions for each application to be determined by the researcher