AdipoGen Life Sciences

FGF-23 (mouse):Fc (human) (rec.)

Product Code:
 
AG-40A-0128Y
Product Group:
 
Recombinant Proteins
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Shipping:
 
Blue Ice
Storage:
 
+4°C
1 / 1
ERK and FRS2alpha phosphorylation induced by FGF-23 in Klotho expressing cells. Klotho expressing HEK 293EBNA cells were serum starved for 16hr and then stimulated with mFGF-23-Fc (Prod. No. AG-40A-0128), and FGF-b (100ng/ml) (positive control) f
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ERK and FRS2alpha phosphorylation induced by FGF-23 in Klotho expressing cells. Klotho expressing HEK 293EBNA cells were serum starved for 16hr and then stimulated with mFGF-23-Fc (Prod. No. AG-40A-0128), and FGF-b (100ng/ml) (positive control) f

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AG-40A-0128Y-C01010 ug£160.00
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AG-40A-0128Y-30103 x 10 ug£310.00
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Further Information

Alternate Names/Synonyms:
Fibroblast Growth Factor 23; Tumor-derived Hypophosphatemia-inducing Factor
Biological Activity:
Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells.
Concentration:
0.1mg/ml after reconstitution.
EClass:
32160000
Endotoxin:
<0.02EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Long Description:
Recombinant protein. Mouse FGF-23 (aa25-251) is fused at the C-terminus to the Fc portion of human IgG1. Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells. Source/Host: HEK 293 cells. Purity: >90% (SDS-PAGE). Lyophilized. Contains PBS. FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
Molecular Weight:
~40kDa (SDS-PAGE); full-length FGF23 is cleaved between Arg179 and Ser 180.
NCBI, Uniprot Number:
Q9EPC2
Package Type:
Plastic Vial
Product Description:
FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
Purity:
>90% (SDS-PAGE)
Sequence:
Mouse FGF-23 (aa25-251) is fused at the C-terminus to the Fc portion of human IgG1.
Source / Host:
HEK 293 cells
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.