Nordic MuBio

Roundabout homolog 1 ROBO1

Product Code:
 
EXA-X2335B
Product Group:
 
Peptides
Supplier:
 
Nordic MuBio
Host Type:
 
Rabbit
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
Ship at ambient temperature freeze upon arrival
Storage:
 
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
 

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EXA-X2335B50 ug£162.00
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Further Information

Applications Description:
For use with ROBO1 polyclonal antibodies (Cat. No. X2313P and X2334P).
Background:
Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development. Defects in ROBO1 may be a cause of breast and lung cancer. ROBO1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Field of Interest:
Neuroscience
Formulation:
Provided as solution in phosphate buffered saline
Functional Analysis:
Western Blotting
Immunogen:
Synthetic peptide derived from human ROBO1 protein
Positive Control:
Widely expressed, with exception of kidney.
Product Form:
Unconjugated
Product Stability:
Products are stable for one year from purchase when stored properly
Synonyms:
H-Robo-1, Deleted in U twenty twenty
UniProt:
Q9Y6N7

References

1. Brose K., Bland K.S., Wang K.H., Arnott D., Henzel W., Goodman C.S., Tessier-Lavigne M., Kidd T.; Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.; Cell 96:795-806(1999).

2. Dallol A., Forgacs E., Martinez A., Sekido Y., Walker R., Kishida T., Rabbitts P., Maher E.R., Minna J.D., Latif F.; Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers.;
Oncogene 21:3020-3028(2002).