Nordic MuBio

Rabbit anti Human Autotaxin

Product Code:
 
EXA-X1653P
Product Group:
 
Primary Antibodies
Supplier:
 
Nordic MuBio
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
Ship at ambient temperature freeze upon arrival
Storage:
 
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
 

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EXA-X1653P100 ug£316.00
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  • Further Information
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Further Information

Applications Description:
Antibody can be used for Western blotting (5-10 ?g/ml) and EIA. Optimal concentration should be evaluated by serial dilutions.
Background:
Autotaxin (ATX), a tumor cell motility- stimulating protein is an ecto/exo-enzyme with significant homology to the plasma cell membrane differentiation antigen PC-1. ATX is a 99kDa core protein and may run as a 125-kDa glycoprotein when isolated from the human melanoma cell line (A2058). ATX, like PC-1 can hydrolyze the type I phosphodiesterase substrate p-nitrophenyl thymidine-5'-monophosphate. Autotaxin has a novel motility- regulating function for this class of ecto/exo-enzymes.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Field of Interest:
Signal Transduction
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Western Blotting
Immunogen:
Synthetic peptide derived from the autotaxin protein
Positive Control:
Human brain lysate (Cat. No. X1633C)
Product Form:
Unconjugated
Product Stability:
Products are stable for one year from purchase when stored properly
Purification Method:
Ammonium Sulfate Precipitation
Synonyms:
EctonucleotAutotaxin (ATX), a tumor cell motility- stimulating protein is an ecto/exo-enzyme with significant homology to the plasma cell membrane differentiation antigen PC-1. ATX is a 99kDa core protein and may run as a 125-kDa glycoprotein when isolate
UniProt:
Q13822

References

[1] Murata J., Lee H.Y., Clair T., Krutzsch H.C., Arestad A.A., Sobel M.E., Liotta L.A., Stracke M.L.; cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases.; J. Biol. Chem. 269:30479-30484(1994).

[2] Lee H.Y., Murata J., Clair T., Polymeropoulos M.H., Torres R., Manrow R.E., Liotta L.A., Stracke M.L.; Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells.; Biochem. Biophys. Res. Commun. 218:714-719(1996).

[3] Kawagoe H., Soma O., Goji J., Nishimura N., Narita M., Inazawa J., Nakamura H., Sano K.;
Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide.; Genomics 30:380-384(1995).

[4] Strausberg R.L., et al Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.; Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).