Nordic MuBio

Rabbit anti Rat G Protein b5-D1

Product Code:
 
EXA-X1594P
Product Group:
 
Primary Antibodies
Supplier:
 
Nordic MuBio
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Shipping:
 
Ship at ambient temperature freeze upon arrival
Storage:
 
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
 

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EXA-X1594P100 ug£316.00
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  • Further Information
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Further Information

Applications Description:
Antibody can be used for Western blotting (5-10 ?g/ml). Optimal concentration should be evaluated by serial dilutions.
Background:
The Gbeta5 protein is a G protein subunit present predominantly in the central nervous system. This protein appears to be expressed in two forms, one found in the brain (39 kDa) and one found in the retina (44 kDa). It has also been found that Gb5 associates tightly with RGS7, a member of the superfamily of negative regulators of G protein signaling. These complexes have been localized to most regions of the brain, whereas G 1-4 exhibit no observable colocalization with RGS7, despite their widespread codistribution throughout similar neuronal networks. This antibody is specific for a peptide sequence within the D1 blade which is not found in the Gbeta?s 1-4.
Caution:
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
Concentration:
See vial for concentration
Field of Interest:
Signal Transduction
Formulation:
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Functional Analysis:
Western Blotting
Immunogen:
Unique peptide sequence derived from the D1 blade of the G 5 protein.
Positive Control:
Plasma membranes from rat cerebrum
Product:
This antibody is specific for a peptide sequence within the D1 blade which is not found in the G betas 1-4. Provided as solution in phosphate buffered saline with 0.08% sodium azide.
Product Form:
Unconjugated
Product Stability:
Products are stable for one year from purchase when stored properly
Purification Method:
Ammonium Sulfate Precipitation
Source:
Rabbits were immunized with a unique peptide sequence derived from the D1 blade of the G 5 protein
UniProt:
O14775

References

1. Liang, J.J., et al. 'RGS7 complex formation and colocalization with the Gbeta5 subunit in the adult rat and influence on Gbeta5gamma2-mediated PLCbeta signaling.' J. Neurosci. Res. 2000: 60, 58-64

2. Cabrera, J.L., et al. 'Identification of the Gbeta5-RGS7 protein complex in the retina.' Biochem Biophys Res Commun. 1998: 249, 898-902

3. Watson, A.J., et al. 'A novel form of the G protein beta subunit Gbeta5 is specifically expressed in the vertebrate retina.' J. Biol. Chem. 1996: 271, 28154-28160