GHR Antibody / Growth Hormone Receptor

Western blot: 1:500-1:2000

Optimal dilution of the GHR antibody should be determined by the researcher.

The GHR gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene. [RefSeq]

Purified

Antibody in PBS with 0.02% sodium azide and 50% glycerol

A synthetic peptide specific to human Growth Hormone Receptor / GHR was used as the immunogen for the GHR antibody.

This GHR antibody is available for research use only.

Affinity purified

Human, Mouse

P10912