ProSci

IL12RB1 Antibody

Product Code:
 
PSI-14-916
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Shipping:
 
Blue Ice or RT
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry of paraffin-embedded rat kidney using IL12RB1 antibody (14-916) at dilution of 1:200 (40x lens).
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Immunofluorescence analysis of MCF7 cells using IL12RB1 antibody (14-916). Blue: DAPI for nuclear staining.
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Immunohistochemistry of paraffin-embedded rat kidney using IL12RB1 antibody (14-916) at dilution of 1:200 (40x lens).
Immunofluorescence analysis of MCF7 cells using IL12RB1 antibody (14-916). Blue: DAPI for nuclear staining.

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PSI-14-916-50uL50uL£433.00
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This product comes from: United States.
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Further Information

Additional Names:
IL12RB1, MGC34454, interleukin-12 receptor beta-1 chain, interleukin 12 receptor, beta 1, IL-12R-BETA1, IL12RB, IL-12 receptor beta component, CD212, IL12R
Application Note:
IHC: 1:50 - 1:200

IF: 1:50 - 1:200
Background:
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-305 of human IL12RB1 (NP_714912.1).
NCBI Gene ID #:
3594
NCBI Official Name:
interleukin 12 receptor, beta 1
NCBI Official Symbol:
IL12RB1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Affinity purification
Research Area:
Chemokines & Cytokines, Immunology, Innate Immunity
Swissprot #:
P42701
User NOte:
Optimal dilutions for each application to be determined by the researcher.