ProSci

UPF1 Antibody

Product Code:
 
PSI-15-057
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Shipping:
 
Blue Ice or RT
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry of paraffin-embedded human liver cancer using UPF1 antibody (15-057) at dilution of 1:100 (40x lens).
2 / 3
Immunohistochemistry of paraffin-embedded mouse brain using UPF1 antibody (15-057) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded mouse heart using UPF1 antibody (15-057) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human liver cancer using UPF1 antibody (15-057) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse brain using UPF1 antibody (15-057) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse heart using UPF1 antibody (15-057) at dilution of 1:100 (40x lens).

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PSI-15-057-50uL50uL£433.00
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Further Information

Additional Names:
UPF1, FLJ43809, FLJ46894, HUPF1, KIAA0221, NORF1, RENT1, pNORF1, smg-2
Application Note:
WB: 1:500 - 1:2000

IHC: 1:50 - 1:200
Background:
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 270-370 of human UPF1 (NP_002902.2).
NCBI Gene ID #:
5976
NCBI Official Name:
UPF1 regulator of nonsense transcripts homolog (yeast)
NCBI Official Symbol:
UPF1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Purification:
Affinity purification
Research Area:
Apoptosis, Cell Cycle
Swissprot #:
Q92900
User NOte:
Optimal dilutions for each application to be determined by the researcher.