Further Information
TRP53, bbl, bfy, bhy, p44, p53, Tp53
WB: 1:500 - 1:2000
IF: 1:10 - 1:100
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 95-390 of mouse p53 (NP_035770.2).
22059
transformation related protein 53
TP53
Mus musculus
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 55kDa
Affinity purification
Apoptosis, Cancer, Cell Cycle, Neuroscience, Signal Transduction, Transcription
Optimal dilutions for each application to be determined by the researcher.