Antibody Clonality:
Polyclonal
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
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United States.
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Further Information
CO4, CPAMD2, Complement C4-A, Acidic complement C4C4, RG, C4S, C4A2, C4A3, C4A4, C4A6, C4AD
WB: 1:500 - 1:2000
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 1200-1446 of human C4A (NP_009224.2).
720
complement component 4A (Rodgers blood group)
C4A
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 192kDa
Affinity purification
Immunology, Innate Immunity
P0C0L4
Optimal dilutions for each application to be determined by the researcher.