ProSci

LIF Recombinant Protein

Product Code:
 
PSI-40-684
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Shipping:
 
Blue Ice or room temp
Storage:
 
The recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing the recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
 

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PSI-40-684-5ug5ug£307.00
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This product comes from: United States.
Typical lead time: 14-21 working days.
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Further Information

Additional Names:
Leukemia Inhibitory Factor, Differentiation-stimulating factor, D factor, Melanoma-derived LPL inhibitor (MLPLI), Interleukin 6 family cytokine
Background:
LIF is a pleiotrophic factor produced by multiple cell types, including T cells, myelomonocytic lineages, fibroblasts, liver, heart and melanoma. LIF promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Other activities include the stimulation of acute phase protein synthesis by hepatocytes, stimulation of differentiation of cholinergic nerves, and suppression of adipogenesis by inhibiting the lipoprotein lipase in adipocytes. While human LIF is active on mouse cells and is widely used in the maintenance of murine ESC to prevent spontaneous differentiation, mouse LIF is not active on human cells due to its inability to bind to the human LIF receptor. Recombinant Human LIF is a 19.7 kDa protein containing 180 amino acid residues, including three disulfide bonds.
Biological Activity:
Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is < 0.1 ng/ml, corresponding to a specific activity of < 1 x 107 units/mg.
NCBI Gene ID #:
3976
NCBI Official Name:
LIF interleukin 6 family cytokine
NCBI Official Symbol:
LIF
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Purity:
> 98% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P15018

Documents