ProSci

IGF-BP-3 Recombinant Protein (Animal Free)

Product Code:
 
PSI-40-710
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Shipping:
 
Blue Ice or room temp
Storage:
 
The recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing the recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
 

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PSI-40-710-5ug5ug£324.00
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This product comes from: United States.
Typical lead time: 14-21 working days.
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Further Information

Additional Names:
Insulin-like Growth, Factor-Binding Protein3, IBP-3, Growth-hormone-dependent binding protein
Background:
IGF-BP3 is a 30 kDa, cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals, and it is also found in α-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors, such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant Human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.
Biological Activity:
Determined by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 is < 0.2 ug/ml in the presence of 15 ng/ml of human IGF-II.
NCBI Gene ID #:
3486
NCBI Official Name:
insulin-like growth factor binding protein 3
NCBI Official Symbol:
IGFBP3
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Purity:
> 98% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P17936

Documents