ProSci

Coagulation factor XI / FXI Recombinant Protein

Product Code:
 
PSI-11-286
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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CodeSizePrice
PSI-11-286-0.05mg0.05mg£867.00
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This product comes from: United States.
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Further Information

Additional Names:
Coagulation factor XI,FXI,PTA,F11
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The proprotein is activated by factor XIIa (or XII) and cleaved after Arg-387 into the light chain with calculated MW of 28.7 kDa, which contains the active site, and the heavy chain with calcula
Background:
Coagulation factor XI is also known as F11, PTA and FXI. Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Factor XI is synthesized in the liver and circulates in the plasma as a disulfide bond-linked dimer complexed with high molecular weight kininogen. Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa. Factor XI is converted into XIa via either the contact phase of blood coagulation or thrombin-mediated activation on the platelet surface. The resulting XIa converts factor IX into IXa, which subsequently activates factor X into Xa.
Background References:
  • Gailani D, et al. J Thromb Haemost. 2009. Suppl 1: 75-8.
  • Emsley J, et al. Blood. 2010. 115(13): 2569-77.
  • Meijers J.C, et al. Biochemistry. 1998. 27:4231-4237.
Buffer:
25 mM HEPES, 150 mM NaCl, pH7.5
Fusion Tag:
His Tag
Physical State:
Lyophilized
Predicted Molecular Weight:
69.9 kDa
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells

Documents