ProSci

Activin RIB / ACVR1B Recombinant Protein

Product Code:
 
PSI-11-236
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-236-0.1mg0.1mg£657.00
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Further Information

Additional Names:
ACVR1b,ALK4,ACVRLK4,ACTR-IB,SKR2
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13.3 kDa. The protein migrates as 16-22 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is ?ATP + [receptor-protein] = ADP + [receptor-protein] phosphate?. ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1.
Background References:
  • Carcamo J., et al., 1994, Mol. Cell. Biol. 14:3810-3821.
  • Suzuki K., et al., 2010, Biochem. Biophys. Res. Commun. 394:639-645.
  • Harrison C.A., et al., 2003, J. Biol. Chem. 278:21129-21135.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
91
NCBI Official Name:
activinAreceptortype1B
NCBI Official Symbol:
ACVR1B
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
13.3 kDa
Protein Accession #:
AAH00254
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P36896

Documents