ProSci

CD45 / PTPRC Recombinant Protein

Product Code:
 
PSI-11-133
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-133-0.1mg0.1mg£729.00
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Further Information

Additional Names:
CD45,PTPRC,L-CA,T200
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 62.8 kDa. The protein migrates as 120-170 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen. CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.
Background References:
  • Shen F.W. et al. Immunogenetics 24 (1986) 146?149.
  • Charbonneau H. et al. Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 7182?7186.
  • Rheinl?nder A. et al. Immunol Lett. 2018 Apr; 196:22-32.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
5788
NCBI Official Name:
proteintyrosinephosphatasereceptortypeC
NCBI Official Symbol:
PTPRC
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
62.8 kDa
Protein Accession #:
NP_002829.3
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P08575

Documents