ProSci

MERTK / Mer Recombinant Protein

Product Code:
 
PSI-11-309
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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CodeSizePrice
PSI-11-309-0.1mg0.1mg£657.00
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Further Information

Additional Names:
MERTK,Mer
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 54.5 kDa. The protein migrates as 70-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Tyrosine-protein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Background References:
  • Graham DK, et al. Cell Growth Differ. 1994. 5(6):647-57.
  • Shimojima M, et al. J Virol. 2006. 80(20):10109-16.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
10461
NCBI Official Name:
MERproto-oncogene,tyrosinekinase
NCBI Official Symbol:
MERTK
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
54.5 kDa
Protein Accession #:
NP_006334.2
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q12866

Documents