ProSci

Unconjugated TPBG / 5T4 Recombinant Protein

Product Code:
 
PSI-11-415
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-415-0.05mg0.05mg£626.00
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Further Information

Additional Names:
TPBG,5T4,M6P1,5T4AG,WAIF1,5T4 oncofetal antigen,Trophoblast glycoprotein,5T4 oncofetal trophoblast glycoprotein
Application Note:
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 39.0 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues.This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. TPBG is expressed by all types of trophoblasts as early as 9 weeks of development.
Background References:
  • Hu G, et al., 2015, Mol Pharm., 12(6), 1730-7.
  • Stern PL, et al., 2017, Cancer Immunol Immunother., 66(4), 415-426.
  • Stern PL, et al., 2014, Semin Cancer Biol., 29, 13-20.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag & Avi Tag
NCBI Gene ID #:
7162
NCBI Official Name:
trophoblast glycoprotein
NCBI Official Symbol:
TPBG
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
39.0 kDa
Protein Accession #:
NP_001159864.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q13641

Documents