ProSci

ZNRF3 Recombinant Protein

Product Code:
 
PSI-11-135
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-135-0.1mg0.1mg£729.00
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Further Information

Additional Names:
ZNRF3, Zinc/RING finger protein 3, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, RNF203
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 19.7 kDa. The protein migrates as 22-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
The transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) is a negative feedback regulator of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6 and acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway.
Background References:
  • Hao H.X. et al. 2012. Nature. 485 (7397): 195?200.
  • Serra S.& Chetty R. 2018. Journal of Clinical Pathology 71 (1): 1?6.
  • Hao H.X. et al. 2016. Cancers (Basel) 8 (6).
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
84133
NCBI Official Name:
zincandringfinger3
NCBI Official Symbol:
ZNRF3
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
19.7 kDa
Protein Accession #:
NP_001193927.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q9ULT6

Documents