ProSci

CTGF / CCN2 Recombinant Protein

Product Code:
 
PSI-11-427
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-427-0.1mg0.1mg£729.00
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This product comes from: United States.
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Further Information

Additional Names:
CCN2,NOV2,HCS24,IGFBP8,IBP-8,IGFBP-8,IGF-binding protein 8
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.4 kDa. The protein migrates as 38-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.
Background References:
  • Faith Hall-Glenn., et?al. 2011, Cell Mol Life Sci., 68(19), 3209?3217.
  • Nakanishi T., et?al. 2000, Endocrinology., 141(1), 264-73.
  • Ball DK., et?al. 2000, J Endocrinol., 176(2), R1-7.
Buffer:
Tris?with?Potassium?glutamate?and?Arginine,?pH7.0
Fusion Tag:
His Tag
Physical State:
Lyophilized
Predicted Molecular Weight:
37.4 kDa
Protein Accession #:
NP_001892.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells

Documents