ProSci

LIGHT / TNFSF14 Recombinant Protein

Product Code:
 
PSI-11-456
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-456-0.1mg0.1mg£729.00
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This product comes from: United States.
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Further Information

Additional Names:
CD258 antigen,CD258,HVEM-L,LIGHT,LTg,TNFSF14,TR2,HVEML
Application Note:
This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 45.1 kDa. The protein migrates as 50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.
Background References:
  • Mauri DN.,?et al.?1998, Immunity., 8, 21-30.
  • Granger SW.,?et al.?2003, Cytokine Growth Factor Rev., 14(3-4), 289-96.
  • Pasero C.,?et al.?2009, Curr Mol Med., 9(7), 911-27.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Mouse IgG Fc Tag
NCBI Gene ID #:
8740
NCBI Official Name:
TNF superfamily member 14
NCBI Official Symbol:
TNFSF14
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
45.1 kDa
Protein Accession #:
NP 003798.2
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
O43557

Documents