ProSci

CLEC12A / MICL / CLL-1 Recombinant Protein

Product Code:
 
PSI-11-264
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-264-0.05mg0.05mg£729.00
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Further Information

Additional Names:
CLEC12A,MICL,CLL-1,CLL1,DCAL2,DCAL-2,CD371
Application Note:
This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 50.2 kDa. The protein migrates as 55-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.
Background References:
  • Toft-Petersen M, et al. 2016. Br J Haematol. 175(3):393-401.
  • Neumann K, et al. 2014. Immunity. 40(3):389-99.
  • Chen CH, et al. 2006. Blood. 107(4):1459-67.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
160364
NCBI Official Name:
C-type lectin domain family 12 member A
NCBI Official Symbol:
CLEC12A
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
50.2 kDa
Protein Accession #:
NP_612210.4
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q5QGZ9

Documents