ProSci

GUCY2C / Guanylyl cyclase C Recombinant Protein

Product Code:
 
PSI-11-229
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-229-0.1mg0.1mg£729.00
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This product comes from: United States.
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Further Information

Additional Names:
GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 72.5 kDa. The protein migrates as 80-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.
Background References:
  • Magee MS, et al. Cancer Immunol Res. 2018. 6(5):509-516.
  • Li P, et al. Cancer Res. 2017. 77(18):5095-5106.
  • Arshad N, et al. J Biol Chem. 2013. 288(6):3907-17.
Buffer:
50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
2984
NCBI Official Name:
guanylatecyclase2C
NCBI Official Symbol:
GUCY2C
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
72.5 kDa
Protein Accession #:
NP_004954.2
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P25092

Documents