ProSci

IL-12 R beta 1 / CD212 Recombinant Protein

Product Code:
 
PSI-11-385
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-385-0.1mg0.1mg£626.00
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Further Information

Additional Names:
IL-12 R beta 1,IL12RB1,CD212,IL12R,IL12RB,IL-12RB1
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 59.0 kDa. The protein migrates as 66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12 R beta 1 (Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
Background References:
  • Presky DH, et al. 1996. Proc Natl Acad Sci U S A. 93(24):14002-7.
  • Parham C, rt al. 2002. J Immunol. 168(11):5699-708.
  • Reeme AE, et al. 2018. Genes Immun. doi: 10.1038/s41435-018-0023-2.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
3594
NCBI Official Name:
interleukin 12 receptor subunit beta 1
NCBI Official Symbol:
IL12RB1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
59.0 kDa
Protein Accession #:
NP_005526.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P42701

Documents