ProSci

IL-22 Recombinant Protein

Product Code:
 
PSI-11-396
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-396-0.05mg0.05mg£729.00
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Further Information

Additional Names:
IL-22,IL-TIF,ZCYTO18
Application Note:
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.6 kDa. The protein migrates as 28-34 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.
Background References:
  • Pestka S., et al., 2004, Annu. Rev. Immunol. 22: 929?79.
  • Witte K., et al., 2010, Cytokine Growth Factor Rev 21 (4): 237?51.
  • Moore KW., et al., 2001, Annu. Rev. Immunol. 19: 683?765.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
50616
NCBI Official Name:
interleukin 22
NCBI Official Symbol:
IL22
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
18.6 kDa
Protein Accession #:
NP_065386.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q9GZX6

Documents